Lengthening Time a Drug Remains Bound to a Target May Lead to Improving Diagnostics, Therapy

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Tonge, together with collaborators at Colorado State University and the University of Würzburg in Germany, have developed a series of compounds that inhibit an enzyme target from Francisella tularensis, where the in vivo antibacterial activity of the compounds correlates with their residence time on the target and not with their thermodynamic affinity for the target.

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