Such a chimera could bring important scientific benefits. The SCID-hu mouse, though it hasn’t yielded a cure for AIDS, has been “a very valuable animal model,” says Ramesh Akkina of Colorado State University, Fort Collins, who directs a lab that uses this part-human mouse. “It has human T cells circulating, which will allow us to test gene therapy for AIDS” in a way that will be more relevant to patients than all-animal models.

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